Structural Biology Group

Vesicular Protein Transport



The biogenesis of membranes, the delivery of proteins to specific cellular compartments, protein secretion and endocytosis are mediated by vesicular intermediates. The formation of transport vesicles, their correct targeting and the specificity of membrane fusion events require multicomponent transport machineries. Many of their components are highly conserved from the unicellular yeast to human brain cells. Our current research is focused on so-called Ypt/Rab-proteins and their interacting effector proteins for complex formation.