Structural Biology Group

Protein chemistry and chemical tools

p21_caged_nbd_xsticks2.jpgThis work is concerned with the development and application of derivatives of natural products as tools for modifying of proteins and nucleic acids for studying structure-function relationships of biomacromolecules. For time-resolved and kinetic crystallography as well as for biophysical characterization of proteins and protein complexes the modification of proteins and their ligands is frequently needed. The main applications are the incorporation of heavy atom into biomacromolecules useful for solving the phase problem in X-ray crystallography and the site-directed incorporation of chromophor labeled amino acids for spectroscopic detection systems.