Arbeitsgruppe Strukturbiologie

Forschung der Abteilung Strukturbiologie

The major focus of our research is related to the characterization of the so called structure-function-relationship of bio-macromolecules. For the determination of the three-dimensional structure we are using X-ray single crystal diffraction. The functional characterization of the enzymatic activity and/or complex formation with other bio-macromolecules we make use of different biophysical methods like affinity chromatography, fluorescence spectroscopy, surface plasmon resonance spectroscopy and mass spectrometry. In our laboratory we have access to all equipment needed in molecular biology (PCR, sequencing, gel imaging), expression (10 l fermentation and different incubators), purification (different Äkta systems and HPLC), crystallization (Mosquito), X-ray data collection (MarµX) and structure refinement.