Structural Biology Group

Structure-Activity Studies on DNA Methyltransferases




In cooperation with Professor Elmar Weinhold (RWTH Aachen) we are investigating the structure-function- relationship of DNA methyltransferases (MTases). DNA methylation has many biological functions, including protection against endogenous restriction endonucleases, directing DNA mismatch repair after replication and regulation of gene expression. Whereas the transfer of the activated methyl group of the cofactor S-adenosyl-L-methionine (AdoMet) to the extracyclic amino group of adenine (N6-DNA MTases) is well investigated, the removal of methylgroups from nucleotide bases is less well understood.